产品货号：
GS4463
中文名称：
重组人IGF-1
英文名称：
Recombinant Human Insulin-like Growth Factor-1
产品规格：
20μg|100μg
发货周期：
1～3天
产品价格：
询价
分子量：Approximately 7.6kDa,a single non-glycosylated polypeptide chain containing 70 amino acids.
储存条件：冷冻（-20℃）
概述
The insulin-like growth factors(IGFs)belonged to the insulin gene family,are mitogenic polypeptide growth factors that stimulate the proliferation and survival of various cell types including muscle,bone,and cartilage tissue in vitro.The IGFs are similar by structure and function to insulin,but have a much higher growth-promoting activity than insulin.IGF-1 is produced primarily by the liver as an endocrine hormone as well as in target tissues in a paracrine/autocrine fashion.The production of IGF-1 is stimulated by growth hormone(GH)and can be retarded by undernutrition,growth hormone insensitivity,lack of growth hormone receptors,or failures of the downstream signaling pathway post GH receptor including SHP2 and STAT5B.Recombinant human IGF-1 are globular proteins containing 70 amino acids and 3 intra-molecular disulfide bonds.Mature human IGF-1 shares 94%and 96%a.a.sequence identity with mouse and rat IGF-1,respectively,and exhibits cross-species activity.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
相关搜索：重组人IGF-1，IGF-1, Human，Recombinant Human Insulin-like Growth Factor-1
储存条件：冷冻（-20℃）
概述
The insulin-like growth factors(IGFs)belonged to the insulin gene family,are mitogenic polypeptide growth factors that stimulate the proliferation and survival of various cell types including muscle,bone,and cartilage tissue in vitro.The IGFs are similar by structure and function to insulin,but have a much higher growth-promoting activity than insulin.IGF-1 is produced primarily by the liver as an endocrine hormone as well as in target tissues in a paracrine/autocrine fashion.The production of IGF-1 is stimulated by growth hormone(GH)and can be retarded by undernutrition,growth hormone insensitivity,lack of growth hormone receptors,or failures of the downstream signaling pathway post GH receptor including SHP2 and STAT5B.Recombinant human IGF-1 are globular proteins containing 70 amino acids and 3 intra-molecular disulfide bonds.Mature human IGF-1 shares 94%and 96%a.a.sequence identity with mouse and rat IGF-1,respectively,and exhibits cross-species activity.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 | Sterile Filtered White lyophilized(freeze-dried)powder. |
| 纯度 | ＞97%by SDS-PAGE and HPLC analyses. |
| 来源 | Escherichia coli. |
| 生物活性 | Fully biologically active when compared to standard.The ED50 as determined by a cell proliferation assay using serum free human MCF-7 cells is less than 2ng/ml,corresponding to a specific activity of>5.0×105 IU/mg. |
| 成分 | Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.4. |
| 内毒素 | Less than 1 EU/μg of rHuIGF-1 as determined by LAL method. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 | GPETLCGAEL VDALQFVCGD RGFYFNKPTG YGSSSRRAPQ TGIVDECCFR SCDLRRLEMY CAPLKPAKSA |
相关搜索：重组人IGF-1，IGF-1, Human，Recombinant Human Insulin-like Growth Factor-1